Leptomeningeal carcinomatosis from oesophageal cancer, presenting as meningitis
| Autor: | Abdel Rahman Omer, Ishtiaque Amin Khan, Mashrafi Ahmed, Tahmina Begum |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Esophageal Neoplasms Adenocarcinoma Malignancy Article 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans Treatment Failure Pleocytosis Neck pain medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease 030104 developmental biology Meningeal carcinomatosis Female Radiology medicine.symptom business Tomography X-Ray Computed Nuchal rigidity Meningitis Meningeal Carcinomatosis 030217 neurology & neurosurgery |
| Zdroj: | BMJ case reports. 2016 |
| ISSN: | 1757-790X |
| Popis: | A 47-year-old woman presented with headache, neck pain, dizziness, nausea and vomiting for 4–5 days. She also had a history of weight loss and difficulty in swallowing. On physical examination, she had nuchal rigidity with a positive Kernig9s sign. Cerebrospinal fluid analysis revealed mild pleocytosis but some atypical cells were also noted. Cytopathological analysis of the atypical cells showed high nuclear/cytoplasmic ratios and eccentric nuclei with prominent nucleoli, consistent with malignancy. A CT scan of the head and neck showed multiple lytic lesions involving the left calvarium, and diffuse thickening and enhancement of meninges over the left cerebral area. Extensive osteolytic lesions were also noted on the vertebral bodies, pedicles and lamina, at multiple levels of the cervical spine. An endoscopy revealed a mass at the gastro-oesophageal junction, and biopsy confirmed moderately differentiated adenocarcinoma of the oesophagus. The patient was started on chemotherapy along with radiation therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|