Boron biodistribution study in colorectal liver metastases patients in Argentina
| Autor: | M. Itoiz, A. Schwint, A. Monti Hughes, M.D. Pereira, Jorge E. Cardoso, P. Sanchez, S.J. Liberman, Eduardo Bumaschny, E. Heber, E. Pozzi, V. Trivillin, S. Nievas |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Boron Compounds
Male inorganic chemicals Radiation-Sensitizing Agents Pathology medicine.medical_specialty Biodistribution Phenylalanine medicine.medical_treatment Argentina chemistry.chemical_element Boron Neutron Capture Therapy Isotopes of boron Adenocarcinoma In Vitro Techniques Transplantation Autologous Isotopes Humans Medicine Tissue Distribution Infusions Intravenous Boron Pre and post Aged Radiation business.industry Liver Neoplasms Middle Aged Biological materials Liver Transplantation Radiation therapy Boron concentration Liver chemistry Female Colorectal Neoplasms business Nuclear medicine Perfusion |
| Zdroj: | Applied Radiation and Isotopes. 67:S76-S79 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/j.apradiso.2009.03.021 |
| Popis: | Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8–3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver⩽ 15 Gy-Eq and tumor⩾40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6±1)×10 9 n cm −2 s −1 ), ex-situ treatment of liver metastases at RA-3 would be feasible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect