Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium
| Autor: | P J Lindholm-Levy, L B Heifets, R D Comstock |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.drug_class
Antibiotics Mycobacterium avium-intracellulare infection Microbial Sensitivity Tests Microbiology Clarithromycin medicine Humans Pharmacology (medical) Mycobacterium avium-intracellulare Infection Antibacterial agent Pharmacology Acquired Immunodeficiency Syndrome biology Aminoglycoside Mycobacterium avium Complex bacterial infections and mycoses biology.organism_classification medicine.disease Drug Combinations Infectious Diseases Gentamicin Gentamicins Bacteria Research Article Mycobacterium medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 36:1695-1698 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.36.8.1695 |
| Popis: | The inhibitory activity of gentamicin against Mycobacterium avium depended on the pH of the medium, and the broth-determined MICs for 90% of strains were 5.0 micrograms/ml at pH 7.4, 9.5 micrograms/ml at pH 6.8, and greater than 16.0 micrograms/ml at pH 5.0. The MBCs were two- to eightfold higher than the MICs. The combined effect of gentamicin and clarithromycin was additive, and the MICs and MBCs of each drug were either the same as those in the single-drug tests or reduced twofold. |
| Databáze: | OpenAIRE |
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