An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men
Autor: | Nichole M. Nusbacher, C. Preston Neff, Andrew P. Fontenot, Catherine A. Lozupone, Sam X. Li, Thomas B. Campbell, Brent E. Palmer, Christine Griesmer, Suzanne Fiorillo, Jennifer M. Schneider, Abigail J. S. Armstrong, Michael Shaffer |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Art initiation 030106 microbiology Population Human immunodeficiency virus (HIV) medicine.disease_cause Microbiology lcsh:Microbial ecology Men who have sex with men Antiretroviral therapy (ART) 03 medical and health sciences Medical microbiology Prevotella Medicine Microbiome education 030304 developmental biology 0303 health sciences education.field_of_study biology Men who have sex with men (MSM) 030306 microbiology business.industry Research Confounding virus diseases biology.organism_classification 3. Good health 030104 developmental biology Lifestyle factors Immunology lcsh:QR100-130 business |
Zdroj: | Microbiome, Vol 6, Iss 1, Pp 1-16 (2018) Microbiome |
ISSN: | 2049-2618 |
Popis: | BackgroundGut microbiome characteristics associated with HIV infection are of intense research interest but a deep understanding has been challenged by confounding factors across studied populations. Notably, a Prevotella-rich microbiome described in HIV-infected populations is now understood to be common in men who have sex with men (MSM) regardless of HIV status, but driving factors and potential health implications are unknown.ResultsHere we further define the MSM-associated gut microbiome and describe compositional differences between the fecal microbiomes of Prevotella-rich MSM and non-MSM that may underlie observed pro-inflammatory properties. Furthermore, we show relatively subtle gut microbiome changes in HIV infection in MSM and women that include an increase in potential pathogens that is ameliorated with antiretroviral therapy (ART). Lastly, using a longitudinal cohort, we describe microbiome changes that happen after ART initiation.ConclusionsThis study provides an in-depth characterization of microbiome differences that occur in a US population infected with HIV and demonstrates the degree to which these differences may be driven by lifestyle factors, ART and HIV infection itself. Understanding microbiome compositions that occur with sexual behaviors that are high-risk for acquiring HIV and untreated and ART-treated HIV infection will guide the investigation of immune and metabolic functional implications to ultimately target the microbiome therapeutically. |
Databáze: | OpenAIRE |
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