A fully transparent, flexible PEDOT:PSS-ITO-Ag-ITO based microelectrode array for ECoG recording
| Autor: | Wen Li, Qi Hua Fan, Yaoyao Jia, Weiyang Yang, Zhen Qiu, Maheshwar Shrestha, Yan Gong, Cheng-You Yao, Arthur J. Weber |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Silver Polymers Biomedical Engineering Bioengineering 02 engineering and technology Biochemistry Capacitance law.invention 03 medical and health sciences PEDOT:PSS law Animals Electrical conductor 030304 developmental biology 0303 health sciences business.industry Graphene Tin Compounds General Chemistry Multielectrode array 021001 nanoscience & nanotechnology Bridged Bicyclo Compounds Heterocyclic Indium tin oxide Rats Microelectrode Electrode Optoelectronics 0210 nano-technology business Microelectrodes |
| Zdroj: | Lab on a chip. 21(6) |
| ISSN: | 1473-0189 |
| Popis: | Integrative neural interfaces combining neurophysiology and optogenetics with neural imaging provide numerous opportunities for neuroscientists to study the structure and function of neural circuits in the brain. Such a comprehensive interface demands miniature electrode arrays with high transparency, mechanical flexibility, electrical conductivity, and biocompatibility. Conventional transparent microelectrodes made of a single material, such as indium tin oxide (ITO), ultrathin metals, graphene and poly-(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS), hardly possess the desired combination of those properties. Herein, ultra-flexible, highly conductive and fully transparent microscale electrocorticogram (μECoG) electrode arrays made of a PEDOT:PSS-ITO-Ag-ITO assembly are constructed on thin parylene C films. The PEDOT:PSS-ITO-Ag-ITO assembly achieves a maximum ∼14% enhancement in light transmission over a broad spectrum (350-650 nm), a significant reduction in electrochemical impedance by 91.25%, and an increase in charge storage capacitance by 1229.78 μC cm-2. Peeling, bending, and Young's modulus tests verify the enhanced mechanical flexibility and robustness of the multilayer assembly. The μECoG electrodes enable electrical recordings with high signal-to-noise ratios (SNRs) (∼35-36 dB) under different color photostimulations, suggesting that the electrodes are resilient to photon-induced artifacts. In vivo animal experiments confirm that our array can successfully record light-evoked ECoG oscillations from the primary visual cortex (V1) of an anesthetized rat. |
| Databáze: | OpenAIRE |
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