Fish oil ameliorates renal injury and hyperlipidemia in the Milan normotensive rat model of focal glomerulosclerosis
| Autor: | D J Sandstrom, David C. Wheeler, David J. Salant, Hiroshi Kawachi, D. J. Goldstein |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Thromboxane Hyperlipidemias Excretion Random Allocation Fish Oils Internal medicine Hyperlipidemia medicine Albuminuria Animals Serum Albumin Proteinuria Glomerulosclerosis Focal Segmental business.industry General Medicine medicine.disease Fish oil Lipids Rats Microscopy Electron Endocrinology Hematocrit Nephrology Creatinine medicine.symptom business Nephritis Nephrotic syndrome |
| Zdroj: | Journal of the American Society of Nephrology. 6:1468-1475 |
| ISSN: | 1046-6673 |
| Popis: | Rats of the Milan normotensive rat strain (MNS) spontaneously develop severe proteinuria and excessive glomerular thromboxane (Tx)A(2) production at a young age. These abnormalities are accompanied by podocyte alterations, progressive focal glomerulosclerosis (FGS), and interstitial fibrosis, resembling human FGS. Since it has been shown that pharmacologic Tx-synthase inhibition protects MNS rats from these changes, it was hypothesized that a fish oil (FO) enriched diet, by enhancing TxA(3) production instead of TxA(2), might afford similar protection, compared with diets enriched in safflower oil (SO) or lard (LD). Rats were pair-fed 11% fat diets from age of 1 to 11 months. Glomerular TxA(2) at 11 months was significantly lower in PO-fed rats than in SO- and LD-fed rats (11 +/- 3.0, 69 +/- 3.0, 59 +/- 19.0 nanograms per min/mg, respectively; P < 0.001). At 3 months, urinary albumin excretion was similar among the groups. Over the course of the study, rats fed FO developed significantly less albuminuria than the SO and LD groups (P < 0.001 by analysis of variance for repeated measures), such that the values at 11 months were 25 +/- 5.8, 49 +/- 8.7, and 68 +/- 13.0 mg/24h, respectively. Serum cholesterol and triglycerides were also significantly lower in FO-fed rats than in SO- and LD-fed rats. The extent of FGS was similar in the three groups, but FO-fed rats had less interstitial injury than the other groups. It was observed that a fish-oil diet substantially alleviated albuminuria, normalized nephrotic hyperlipidemia, and reduced interstitial injury, but did not prevent the development of FGS in the MNS model. |
| Databáze: | OpenAIRE |
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