Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice
| Autor: | Kazufumi Toume, Tsugunobu Andoh, Shizuka Mizoguchi, Daisuke Uta, Yasushi Kuraishi, Ryo Kitamura, Katsuko Komatsu, Mitsuru Kato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
Exacerbation Side effect Paclitaxel medicine.medical_treatment Short Communication Intraperitoneal injection Plantaginis Semen lcsh:Medicine Pharmacology complex mixtures 01 natural sciences Allodynia Aucubin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration medicine business.industry lcsh:R medicine.disease Catalpol 0104 chemical sciences 010404 medicinal & biomolecular chemistry Peripheral neuropathy Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Journal of Traditional and Complementary Medicine Journal of Traditional and Complementary Medicine, Vol 6, Iss 3, Pp 305-308 (2016) |
| ISSN: | 2225-4110 |
| Popis: | The chemotherapeutic agent paclitaxel (PTX) causes peripheral neuropathy as a major dose-limiting side effect, and this peripheral neuropathy is difficult to control. Our previous report showed that prophylactic repetitive administration of goshajinkigan (牛車腎氣丸 niú chē shèn qì wán), but not hachimijiogan (八味地黃丸 bā wèi dì huáng wán), which lacks two of the constituents of goshajinkigan, inhibited PTX-induced mechanical allodynia in mice. Thus, the herbal medicines Plantaginis Semen (車前子 chē qián zǐ) or Achyranthis Radix (牛膝 niú xī) may contribute to the inhibitory action of goshajinkigan on the exacerbation of PTX-induced mechanical allodynia [Andoh et al, J. Tradit. Complement. Med. 2014; 4: 293–297]. Therefore, in this study, we examined whether an extract of Plantaginis Semen (EPS) or Achyranthis Radix (EAR) would relieve PTX-induced mechanical allodynia in mice. A single intraperitoneal injection of PTX caused mechanical allodynia, which peaked on day 14 after injection. Repetitive oral administration of EPS, but not EAR, starting from the day after PTX injection significantly inhibited the exacerbation of PTX-induced mechanical allodynia. Repetitive intraperitoneal injection of aucubin, one of the main components of EPS, starting from the day after PTX injection also significantly reduced PTX-induced mechanical allodynia. However, repetitive intraperitoneal injection of geniposide acid (a precursor of aucubin) or catalpol (a metabolite of aucubin) did not prevent the exacerbation of mechanical allodynia. These results suggest that prophylactic administration of EPS is effective for preventing the exacerbation of PTX-induced allodynia. Aucubin may contribute to the inhibitory action of EPS on the exacerbation of PTX-induced allodynia. Graphical abstract |
| Databáze: | OpenAIRE |
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