Early Administration of Infliximab for Severe Ipilimumab-Related Diarrhea in a Critically Ill Patient
| Autor: | Paul M. Reynolds, Scott W. Mueller, R. William Vandivier, Steven P. Merrill, Jason R. Biehl, Avash Kalra |
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| Rok vydání: | 2014 |
| Předmět: |
Diarrhea
Male medicine.medical_specialty Resuscitation Critical Illness Antineoplastic Agents Autoimmune Diseases Gastrointestinal Agents medicine Humans Pharmacology (medical) Melanoma Aged Acidosis Gastrointestinal agent business.industry Acute kidney injury Antibodies Monoclonal Metabolic acidosis Common Terminology Criteria for Adverse Events Acute Kidney Injury Colitis medicine.disease Ipilimumab Infliximab Surgery Anesthesia Hypotension medicine.symptom business medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 48:806-810 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1177/1060028014528152 |
| Popis: | Objective: To report a case of ipilimumab-associated life-threatening diarrhea responding quickly to a single dose of infliximab. Case Summary: A 67-year-old man presented 3 weeks after his second dose of ipilimumab with severe diarrhea, acute kidney injury, and hypotension. After 2 days of high-dose corticosteroids and supportive care, he continued to have 2.8 L of stool output per day (grade 4 National Cancer Institute Common Terminology Criteria for Adverse Events). The patient was transferred to the medical intensive care unit requiring endotracheal intubation because of concerns of worsening mental status, metabolic acidosis, and increased work of breathing, with a serum bicarbonate concentration of |
| Databáze: | OpenAIRE |
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