Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats
| Autor: | Eme Lilian Olu, Niabari Bariburame, Ogunka-Nnoka Charity Uchechi, Igwe Felix Uchenna, Ovuworie Fegor Precious |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Traditional medicine
business.industry Bilirubin Centella asiatica leaf extract Negative control Jaundice CENTELLA ASIATICA LEAF Body weight Excretion chemistry.chemical_compound chemistry Potential Centella asiatica leaf Extract Paracetamol Albino rats Medicine medicine.symptom business Normal control |
| Zdroj: | World Journal of Advanced Research and Reviews. 6:244-254 |
| ISSN: | 2581-9615 |
| DOI: | 10.30574/wjarr.2020.6.1.0122 |
| Popis: | Jaundice is a condition associated with the imbalance between bilirubin production and excretion when the liver is diseased. This study investigated the Potential ofCentella asiaticaleaf extract in the management of paracetamol-induced jaundice in albino rats. The rats were randomly distributed into six groups of five each. Group 1 (normal control- fed with rat feed and water), group 2 (paracetamol 2 g/kg body weight), group 3 (paracetamol 2g/kg bw + silymarin 100 mg/kg bw) and groups 4 – 6 (2g/kg bw each + 200, 400 and 600 mg/kg bw of CaL- extract respectively). The Paracetamol was first administered to the rats for 5 days to establish jaundice followed by administration of silymarin and CaL- extract for 10 days before sacrifice. The group 2 (negative control) rats had significant increase (p12/L) and platelet (248.00±1.00 x109/L) as well as elevated levels of serum lipids (LDL, TG,TC VLDL-cholesterol) when compared with group 3 and the CaL-treated groups. Results of the liver function maker enzymes (AST, ALT and ALP) activity, serum bilirubin and proteins as well as renal function indices (creatinine, urea, chloride and bicarbonate) in group 2 were significantly increased (p |
| Databáze: | OpenAIRE |
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