Surveillance of invasive Neisseria meningitidis with a serogroup Y update, Sweden 2010 to 2012
| Autor: | Per Olcén, S Thulin Hedberg, Bianca Törös, Susanne Jacobsson, Hans Fredlund, Paula Mölling |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Adolescent Genotype Epidemiology Minisatellite Repeats Neisseria meningitidis medicine.disease_cause Serogroup Polymerase Chain Reaction Microbiology Neisseria meningitidis serogroup Y Disease Outbreaks Young Adult Virology medicine Humans Serotyping Child Aged Aged 80 and over Sweden business.industry Incidence Public Health Environmental and Occupational Health Infant Newborn Infant Sequence Analysis DNA Middle Aged Meningococcal Infections Invasive meningococcal disease Child Preschool Female business Sentinel Surveillance Multilocus Sequence Typing |
| Zdroj: | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 19(42) |
| ISSN: | 1560-7917 |
| Popis: | An increase of invasive meningococcal disease caused by Neisseria meningitidis serogroup Y has been noted in Sweden since 2005, and to a lower extent throughout Europe. The present study describes the epidemiology of invasive N. meningitidis isolates in Sweden in the period between 2010 and 2012, with a focus on serogroup Y. We also aimed to find an optimal molecular typing scheme for both surveillance and outbreak investigations. All invasive N. meningitidis isolates in Sweden during the study period (n=208) were genetically characterised. Serogroup Y predominated with 22/57, 31/61 and 44/90 of all invasive isolates (incidence 0.23, 0.33 and 0.46 per 100,000 population) in 2010, 2011 and 2012 respectively. In each of these years, 15/22, 22/31 and 19/44 of serogroup Y isolates were genetically clonal (Y: P1.5–2,10–1,36–2: F4–1: ST-23(cc23), ‘porB allele 3–36, fHbp allele 25 and penA allele 22). Our findings further support those of others that currently recommended FetA typing could be replaced by FHbp. Moreover, in line with a previous study that we conducted, the current results indicate that highly variable multilocus variable-number tandem repeat analysis (HV-MLVA) can be used as a first-hand rapid method for small outbreak investigations. |
| Databáze: | OpenAIRE |
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