Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases
| Autor: | Christian Heinis, John Tite, Vanessa Baeriswyl, Greg Winter, Dan Teufel, Shiyu Chen, Catherine Stace, Helen Rapley, Lisa Pollaro, Edward Walker |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Proteases Web of science Biology 01 natural sciences Biochemistry Peptides Cyclic 03 medical and health sciences Bridged Bicyclo Compounds Mice Structure-Activity Relationship Drug Discovery Structure–activity relationship Animals Humans General Pharmacology Toxicology and Pharmaceutics Enzyme Inhibitors Plasma Kallikrein 030304 developmental biology Pharmacology 0303 health sciences Bicyclic molecule 010405 organic chemistry Organic Chemistry Kallikrein 3. Good health 0104 chemical sciences Ring size Human plasma Molecular Medicine Peptide Hydrolases |
| Zdroj: | ChemMedChem |
| DOI: | 10.1002/cmdc.201200071 |
| Popis: | Reference EPFL-ARTICLE-177886doi:10.1002/cmdc.201200071View record in Web of Science Record created on 2012-06-06, modified on 2017-05-12 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|