Cognitive decline before and after a first-ever stroke in Africans
| Autor: | Akin Ojagbemi, Toyin Bello, Olusegun Baiyewu, Mayowa O. Owolabi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gerontology
03 medical and health sciences 0302 clinical medicine Cognition Risk Factors medicine Humans Cognitive Dysfunction 030212 general & internal medicine Cognitive rehabilitation therapy Cognitive decline Stroke Aged Retrospective Studies business.industry Nigerians General Medicine medicine.disease Mental Status and Dementia Tests Neurology Strictly standardized mean difference Africa Observational study Neurology (clinical) business Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Acta neurologica ScandinavicaREFERENCES. 144(3) |
| ISSN: | 1600-0404 |
| Popis: | OBJECTIVES There is a knowledge gap on the impact of pre-existing cognitive decline on poststroke decline in indigenous Africans. We describe the trajectories of domain-specific cognitive and activities of daily life (ADL) functioning across the first year of stroke in Nigerians with pre-existing cognitive decline. MATERIALS AND METHODS Prospective observational study. Prestroke cognitive decline was ascertained retrospectively using the 16-item Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE). Assessments for global cognition, learning, memory, executive and ADL functioning were conducted at 3 time points using the Mini-Mental state examination (MMSE), 10-words list learning and delayed recall test (10 WDRT), Animal naming test and Barthel index, respectively. RESULTS Among 150 stroke survivors, prestroke cognitive decline was found in 25 (16.7%, 95% C.I = 11.5%-23.6%). In linear regression analyses adjusting for the effect of age, education, stroke severity and comorbid diabetes mellitus, prestroke cognitive decline predicted poor memory scores at one year [Adjusted standardized mean difference (SMD) = -0.6, 95% C.I = -1.1, -0.1, p = 0.016)]. The association of prestroke cognitive decline with poststroke poor memory was substantially mediated by age (SMD = -0.9, 95% C.I = -1.4, -0.4, p |
| Databáze: | OpenAIRE |
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