Hyperthyroidism and Thyroid Cancer Risk: A Population-based Cohort Study
Autor: | C.-Y. Yang, S.-Y. Lee, J.-J. Wang, N.-C. Yeh, C.-W. Chou, F.-C. Yen, Shih-Feng Weng, Kai-Jen Tien |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors endocrine system diseases Endocrinology Diabetes and Metabolism Taiwan Hyperthyroidism law.invention Endocrinology Randomized controlled trial Risk Factors law Internal medicine Internal Medicine medicine Humans Thyroid Neoplasms Thyroid cancer Aged Retrospective Studies business.industry Incidence Incidence (epidemiology) Follow up studies Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Surgery National health insurance Cohort Female business Follow-Up Studies |
Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 121:402-406 |
ISSN: | 1439-3646 0947-7349 |
Popis: | Thyroid hormones regulate the rate of metabolism and affect the differentiation and growth of many tissues in the body. We investigated the association between hyperthyroidism and cancer risk in Taiwan.A random sample of 1 000 000 individuals from Taiwan's National Health Insurance database was enrolled. We found 17 033 patients to have newly diagnosed hyperthyroidism between 2000 and 2005. These patients were recruited along with a match cohort of 34 066 patients without hyperthyroidism. Starting from index date, we followed up all patients for 4 years to identify those who developed cancer.During the 4-year follow-up study, cancer was diagnosed in 1.23% of patients with hyperthyroidism and 1.02% of the member of the comparison cohort. Regression analysis showed that patients with hyperthyroidism were at greater risk of cancer incidence, especially thyroid cancer, compared the comparison cohort (HR: 1.213; 95% CI: 1.022-1.440; p0.05 and HR: 7.355; 95% CI: 3.885-13.92; p0.05, respectively). After adjusting for age, gender, diabetes mellitus, hypertension, hyperlipidemia, gout, geographic region, and income, patients with hyperthyroidism remained at increased risk of cancer incidence and thyroid cancer (Adjusted HR: 1.206; 95% CI: 1.015-1.433 and 6.803; 95% CI: 3.584-12.91, respectively) (both p0.05). The longer the duration of hyperthyroidism, the greater the risk of thyroid cancer.This 4-year follow up study suggests that patients with hyperthyroidism are at increased risk of cancer, especially thyroid cancer. |
Databáze: | OpenAIRE |
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