Antagonism of naloxone hyperalgesia by ethanol
| Autor: | Howard J. Friedman, David Lester, M. B. Bass |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Startle response Reflex Startle medicine.medical_treatment Analgesic Variable time (+)-Naloxone Motor Activity General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Saline Analgesics Electroshock Ethanol medicine.diagnostic_test business.industry Naloxone General Medicine Rats Endocrinology chemistry Hyperalgesia medicine.symptom Vocalization Animal Antagonism business |
| Zdroj: | Life sciences. 22(21) |
| ISSN: | 0024-3205 |
| Popis: | Male Sprague-Dawley rats (8 per group) received 1.25 g/kg ethanol (EtOH) in saline or saline alone i.p. and either saline, 0.1, or 2.0 mg/kg naloxone HC1 (NAL) s.c. five min later. Beginning 15 min after the second injection, rats received five noncontingent 0.5 sec footshocks at each of three intensities (0.6, 0.8, 1.3 mA) in a random order on a variable time 1 min schedule. The amplitude of the startle response, number of audible vocalizations, and extent of overt movements were recorded. EtoH significantly reduced startle response amplitude and overt movements at 0.8 and 1.3 mA; NAL failed to antagonize these indices of EtOH analgesia. NAL was itself without effect upon overt movements but significantly increased startle response amplitude and vocalizations at 1.3 mA. EtOH prevented these NAL-induced increases but this does not appear attributable to ethanol's analgesic or motoric effects. Possible mechanisms of ethanol's effects upon endorphin systems are considered. |
| Databáze: | OpenAIRE |
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