Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
| Autor: | Darío Andrinolo, Leda Giannuzzi, Carlos Alberto Marra, Daniela Yazmine Sedan, Luis Horacio Telese, María J.T. de Alaniz |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Microcystins medicine.medical_treatment Microcystin Microcystin-LR Toxicology medicine.disease_cause Antioxidants Mice chemistry.chemical_compound NEFA Internal medicine medicine Animals Homeostasis Saline Ciencias Exactas Glutathione Peroxidase food and beverages Recovery of Function Glutathione Catalase Lipid Metabolism Lipids Oxidative Stress Glutathione Reductase Endocrinology Liver chemistry Oxidative stress Toxicity Antioxidant enzymes Marine Toxins alpha-Tocopherol Injections Intraperitoneal Hepatic damage |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 0041-0101 |
| Popis: | The effects of MC-LR on antioxidant system in liver and kidney and its effects on hepatic lipid composition after prolonged exposure to sublethal doses of microcystins (MCs) were studied in mice. Mice were treated i.p. with 25 mg of MC-LR/kg body weight or saline solution every 2 days for a month (inflictive stage), then progression or recovery was studied for 1 and 2 months of wash-out. During the inflictive stage, MC-LR-induced oxidative damage and significant changes in liver lipids of treated mice were compared with control mice. A clear dependence of the enzyme defense system was demonstrated with reduced glutathione and a-tocopherol availabilities and a concomitant elevation in NOx production. Sub-chronic MC-LR toxicosis produced alterations in lipid components that included a decreased EFA/non-EFA, SFA/PUFA, and n-3/n-6 ratios all of which exhibited a pattern of slow recovery during the recovery periods. Centro de Investigación y Desarrollo en Criotecnología de Alimentos Instituto de Investigaciones Bioquímicas de La Plata |
| Databáze: | OpenAIRE |
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