Induction by LH/hCG of an increase in the rate of pig Leydig cell receptor mRNA degradation
| Autor: | M. Vigier, O. Avallet, H. Schteingart, J. M. Saez, F. Chuzel |
|---|---|
| Přispěvatelé: | Communications Cellulaires et Différenciation (CCD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA), A. Bartke (Editeur), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
LH
endocrine system medicine.medical_specialty Leydig cell urogenital system Chemistry [SDV]Life Sciences [q-bio] luteinizing hormone/choriogonadotropin receptor HCG Human chorionic gonadotropin [SDV] Life Sciences [q-bio] medicine.anatomical_structure Endocrinology Internal medicine medicine Receptor Luteinizing hormone Protein kinase A hormones hormone substitutes and hormone antagonists Intracellular Hormone |
| Zdroj: | Function of somatic cells in the testis Function of somatic cells in the testis, Springer Verlag, 1994 Function of Somatic Cells in the Testis ISBN: 9781461276197 |
| Popis: | Luteinizing hormone (LH) is absolutely required for the maintenance of Leydig cell-specific functions, and this hormone is the main factor that under physiological conditions controls Leydig cell testosterone (T) secretion. It is clear that the ability of LH or human chorionic gonadotropin (hCG), which shares structural, biological, and receptor binding properties with LH (1), to stimulate Leydig cells depends not only on the levels of these hormones, but also on the number and functional activity of the LHIhCG receptor (LH/hCG-R). The interaction of LH/hCG with its receptors initiates a sequence of events at the membrane level, followed by the induction of a number of intracellular events, including activation of adenylate cyclase and cAMP-dependent protein kinase, which is believed to be responsible for most of the effects of the hormone. After the initial stimulation of target cell function, many in vivo and in vitro studies have shown that treatment with LH/hCG also decreases the number of its binding sites and causes desensitization (reviewed in 2, 3). However, the molecular bases of this regulation are poorly understood. |
| Databáze: | OpenAIRE |
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