Nerve Growth Factor Levels in Cerebrospinal Fluid From Patients With Neurologic Disorders
| Autor: | Kenzo Takeshita, Yoshihiro Maegaki, Sakae Narai, Toshiro Hara, Ichiro Suzaki |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Multiple Sclerosis Adolescent Meningitis Bacterial 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid 030225 pediatrics medicine Viral meningitis Humans In patient Nerve Growth Factors Child CSF albumin business.industry Multiple sclerosis Infant Newborn Infant medicine.disease Meningitis Viral Nerve growth factor Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) business Meningitis 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Journal of Child Neurology. 12:205-207 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/088307389701200310 |
| Popis: | Nerve growth factor levels were measured in the cerebrospinal fluid from 73 patients with neurologic disorders and non-neurologic acute illnesses by a two-site enzyme immunoassay. Elevated nerve growth factor levels in cerebrospinal fluid were demonstrated in 2 of 7 patients with bacterial meningitis, 7 of 14 patients with viral meningitis or encephalitis, and 1 with multiple sclerosis. Follow-up examinations of the 3 patients (1 with bacterial meningitis, 1 with viral meningitis, and 1 with multiple sclerosis) at convalescent stage showed diminished nerve growth factor levels in cerebrospinal fluid. None of the other patients showed elevation of nerve growth factor levels in cerebrospinal fluid. Nerve growth factor levels in cerebrospinal fluid were not correlated with cell numbers in patients with meningitis or encephalitis. No relationship was observed between nerve growth factor levels and outcome in patients with viral meningitis or encephalitis and bacterial meningitis. Nerve growth factor in cerebrospinal fluid may play a role in neuronal recovery or function as an immunomodulator in children with inflammatory and immune-mediated neurologic disorders. (J Child Neurol 1997; 12:205-207). |
| Databáze: | OpenAIRE |
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