Risk factors of stillbirth in rural China: A national cohort study
| Autor: | Shikun Zhang, Yimin Qu, Hui Pan, Chengsheng Yan, Huijuan Zhu, Yu Jiang, Shi Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Rural Population 0301 basic medicine China Protective factor lcsh:Medicine Risk Assessment Article Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Environmental health Odds Ratio Humans Medicine Public Health Surveillance Propensity Score lcsh:Science Multidisciplinary business.industry lcsh:R Confounding Odds ratio Middle Aged Stillbirth medicine.disease 030104 developmental biology Propensity score matching Female lcsh:Q business Risk assessment Live birth Live Birth 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | People living in rural China are more frequently exposed to some specific risk factors which made stillbirth rate higher than urban areas. National Free Preconception Health Examination Project was launched to investigate these risk factors and collected a representative sample of 248501 participants from 31 provinces in China from 2010 to 2013. Parental risk factors were ascertained twice before and during pregnancy respectively by questionnaires. Stillbirth or live birth were recorded by trained physicians. In the analysis, nested case-control study was conducted, and propensity score matching method was used to adjust the confounding. Multi-level logistic regression was used to fit for multi-level sampling. The overall stillbirth rate was 0.35% in rural China, it was higher in North (0.42%) and West (0.64%) areas. Maternal exposure to pesticide (OR (95%CI 1.06, 3.39)), hypertension (OR = 1.58 (95%CI 1.07, 2.34)), lack of appetite for vegetables (OR = 1.99 (95%CI 1.00, 3.93)), stress (compared with no pressure, OR of a little pressure was 1.34(95% CI 1.02, 1.76)); paternal exposure to smoking (OR = 1.22 (95% CI 1.02, 1.46)), organic solvents (OR = 1.64 (95% CI 1.01, 2.69)) were found independent risk factors of stillbirth. Folacin intake 3 months before pregnancy (OR = 0.72 (95%) CI 0.59, 0.89), folacin intake 1-2 months before pregnancy (OR = 0.71 (95% CI 0.55, 0.92)), folacin intake after pregnancy (OR = 0.81 (95% CI 0.65, 1.02) for) were protect factors of stillbirth. Maternal pesticide exposure, lack of vegetables, stress, paternal smoking and exposure to organic solvents were risk factors of stillbirth. Folic acid intake was protective factor of stillbirth, no matter when the intake began. |
| Databáze: | OpenAIRE |
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