Detection of in vitro interferon-gamma and serum tumour necrosis factor-alpha in multidrug-resistant tuberculosis patients
| Autor: | T. H. M. Ottenhoff, K. S. Cunha, Afranio Lineu Kritski, Annemieke Geluk, C. L. M. C. Franken, Paulo R. Z. Antas, P. Klatser, K.C. Pereira, Margareth Pretti Dalcolmo, Euzenir Nunes Sarno, Elizabeth P. Sampaio, A. Fortes, M. M. Ribeiro-Carvalho, A. H. J. Kolk |
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| Přispěvatelé: | KIT: Biomedical Research |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Necrosis Tuberculosis medicine.medical_treatment Immunology Antitubercular Agents Statistics Nonparametric Proinflammatory cytokine Mycobacterium tuberculosis Interferon-gamma Bacterial Proteins Antigen Clinical Studies Tuberculosis Multidrug-Resistant Humans Immunology and Allergy Medicine Interferon gamma Cells Cultured Antigens Bacterial biology Tumor Necrosis Factor-alpha business.industry Middle Aged medicine.disease biology.organism_classification Cytokine Case-Control Studies ESAT-6 Leukocytes Mononuclear Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical and experimental immunology, 141(3), 541-548. Wiley-Blackwell |
| ISSN: | 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2005.02872.x |
| Popis: | SummaryMultidrug-resistant tuberculosis (MDR-TB) is known as having a poor prognosis with a weak response to therapy and very high death rates. The aim of this work was to assess the immune response to the RD1-encoded antigen ESAT-6 of Mycobacterium tuberculosis in MDR-TB patients and compare to non-resistant (NR) TB patients and healthy controls (HC). Evaluation of interferon (IFN)-γ production showed that, although 55% of the MDR patients were responsive to ESAT-6, they produced lower IFN-γ levels (553 ± 11 pg/ml) when compared to NR-TB (1179 ± 163 pg/ml; P |
| Databáze: | OpenAIRE |
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