Evaluation of tumor blood flow in musculoskeletal lesions: dynamic contrast-enhanced MR imaging and its possibility when monitoring the response to preoperative chemotherapy-work in progress
| Autor: | Kenshi Sakayama, Makoto Kajihara, Teruhito Mochizuki, Keiichi Kikuchi, Yoshifumi Sugawara, Kenya Murase |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Adolescent medicine.medical_treatment Contrast Media Bone Neoplasms Statistics Nonparametric Diagnosis Differential Preoperative Care medicine Image Processing Computer-Assisted Preoperative chemotherapy Humans Radiology Nuclear Medicine and imaging Child Aged Aged 80 and over Chemotherapy Muscle Neoplasms Radiation medicine.diagnostic_test business.industry Magnetic resonance imaging Blood flow Middle Aged Mr imaging Magnetic Resonance Imaging Radiation therapy Dynamic contrast Contrast medium Oncology Female Radiology business |
| Zdroj: | Radiation medicine. 25(3) |
| ISSN: | 0288-2043 |
| Popis: | The objective of this study was to calculate tumor blood flow (TBF) in musculoskeletal lesions and to evaluate the usefulness of this parameter in differentiating malignant from benign lesions and monitoring the treatment response to preoperative chemotherapy. Altogether, 33 patients with musculoskeletal lesions underwent a total of 50 dynamic magnetic resonance imaging (MRI) examinations, including 28 on 9 patients undergoing preoperative chemotherapy. TBF was calculated using deconvolution analysis. Steepest slope (SS) was determined from the time–intensity curve during the first pass of contrast medium. TBF ranged from 2.7 to 178.6 mL/100 mL/min in benign lesions and from 15.4 to 296.3 mL/100 mL/min in malignant lesions. SS ranged from 0.5%/s to 31.8%/s for benign lesions and from 3.1%/s to 64.8%/sec for malignant lesions. TBF and SS did not differ significantly between benign and malignant lesions. Among the nine patients who underwent preoperative chemotherapy, TBF after chemotherapy was lower in good responders (11.7, 11.0, 7.9 mL/100 mL/min) (n = 3, tumor necrosis ≥90%) than in poor responders (23.4–141.5 mL/100 mL/min) (n = 6, tumor necrosis |
| Databáze: | OpenAIRE |
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