Effect of Polylactic Acid Film Barrier on Intra-Abdominal Adhesion Formation
| Autor: | Mehmet Özdoğan, Vedat Ozturk, Haldun Gündoğdu, Aylin Kilic Yazgan, Eren Ersoy |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Polymers Polyesters medicine.medical_treatment Abrasion (medical) Adhesion (medicine) Tissue Adhesions Inflammation Abdominal wall chemistry.chemical_compound Postoperative Complications Polylactic acid Fibrosis Laparotomy Abdomen medicine Animals Lactic Acid Rats Wistar business.industry medicine.disease Rats Surgery medicine.anatomical_structure chemistry Female medicine.symptom business |
| Zdroj: | Journal of Surgical Research. 147:148-152 |
| ISSN: | 0022-4804 |
| Popis: | The aim of the present study was to evaluate the efficacy of an absorbable polylactic acid film barrier in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.Thirty Wistar albino rats were divided into treatment and control groups. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The treatment group had a polylactic acid film barrier placed between the cecal and abdominal injured surfaces while control group received nothing. The animals were sacrificed on postoperative day 21. Three observers graded the intra-abdominal adhesions and resected specimens for histological examination of fibrosis and inflammation. Fibrosis, inflammation, and adhesions were graded using a quantitative scoring system.The treatment group showed significantly less adhesions and inflammation (P0.05), while there was no significant difference in the amount of fibrosis. Statistical correlations between adhesion-inflammation, adhesion-fibrosis, and inflammation-fibrosis were also significant (P0.05).Placement of polylactic acid film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions and inflammation. This may be a promising result for reducing the morbidity and costs related to postoperative adhesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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