High Prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in East Malaysia: Challenges in Providing Effective Health Care for an Indigenous Group
| Autor: | Yong-Chui Wee, Noor Fadzlin Mahali, Kek Heng Chua, Kim-Lian Tan, Elizabeth George, Ping Chin Lee, Jin-Ai Mary Anne Tan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Article Subject lcsh:Biotechnology Health Toxicology and Mutagenesis Genetic counseling Thalassemia Population Prevalence lcsh:Medicine Prenatal diagnosis Comorbidity Alpha-thalassemia Risk Assessment Indigenous Population Groups alpha-Thalassemia Risk Factors lcsh:TP248.13-248.65 hemic and lymphatic diseases Environmental health Genetics medicine Humans education Molecular Biology education.field_of_study business.industry lcsh:R beta-Thalassemia Malaysia Beta thalassemia General Medicine medicine.disease Molecular Medicine business Research Article Biotechnology |
| Zdroj: | Journal of Biomedicine and Biotechnology Journal of Biomedicine and Biotechnology, Vol 2010 (2010) |
| ISSN: | 1110-7251 1110-7243 |
| DOI: | 10.1155/2010/706872 |
| Popis: | Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia.α- andβ-thalassemia were confirmed in 33.6% and 12.8%, of the individuals studied respectively. The high prevalence ofα- andβ-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia. |
| Databáze: | OpenAIRE |
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