Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India
| Autor: | A.K. Borthakur, Anoop Velayudhan, Lahari Saikia, Prabir Kumar Sen, Padmini Srikantiah, Daiji Gogoi Mohan, Ravi Yadav, Reeta S. Mani, Vijayalakshmi Reddy, A C Dhariwal, Ravi Vasanthapuram, Jagdish Prasad, Bhaswati Bandyopadhyay, Anita Desai, Shafeeq K. Shahul Hameed, Amita Jain, Nemai Bhattacharya, S. Venkatesh, Kayla F. Laserson |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Adolescent viruses 030106 microbiology India Scrub typhus Dengue virus medicine.disease_cause Virus Dengue fever Serology lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences 0302 clinical medicine medicine Acute Febrile Encephalopathy Humans lcsh:RC109-216 030212 general & internal medicine Child Encephalitis Japanese Encephalitis Virus Japanese business.industry Infant General Medicine Dengue Virus Japanese encephalitis medicine.disease Virology Infectious Diseases Herpes simplex virus Child Preschool Etiology Female business |
| Zdroj: | International Journal of Infectious Diseases, Vol 84, Iss, Pp S19-S24 (2019) |
| ISSN: | 1201-9712 |
| Popis: | Background: Acute encephalitis syndrome (AES) surveillance in India has indicated that Japanese encephalitis virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown in the remaining cases. We implemented comprehensive AES surveillance to identify other etiological agents of AES, with emphasis on dengue virus. Methods: Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively in AES surveillance from 2014-2017 at selected sites of three high burden states of India. All samples were initially tested for JEV IgM. Specimens negative for JEV by serology were tested for IgM to scrub typhus, dengue virus (DEN), and West Nile virus; all JEV IgM-negative CSF samples were tested by PCR for S. pneumoniae, N. meningitidis, H. influenzae, herpes simplex virus type 1, enteroviruses and DEN. Results: Of 10,107 AES patients, an etiology could be established in 49.2% of patients including JEV (16%), scrub typhus (16%) and DEN (5.2%) as the top three agents. Amongst the DEN positive cases (359/6892), seven (2%) were positive only for dengue virus RNA: one in serum and six in CSF. Conclusion: Amongst the pathogens identified, dengue accounted for 5% of all AES cases and was one of the three common etiological agents. These results underscore the importance of including dengue virus in routine testing of AES cases. Keywords: Acute encephalitis syndrome, Etiological agents, Dengue, India |
| Databáze: | OpenAIRE |
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