Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
Autor: | Jiangyuan Yuan, Ying Li, Xuanhui Liu, Meng Nie, Weiwei Jiang, Yibing Fan, Tangtang Xiang, Hanhua Wang, Wei Quan, Chuang Gao, Jinghao Huang, Shuo An, Yongxin Ru, Qiufan Zhou, Jianning Zhang, Rongcai Jiang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Statin medicine.drug_class Atorvastatin medicine.medical_treatment Encephalopathy Case Report dexamethasone 03 medical and health sciences 0302 clinical medicine Hematoma medicine Dexamethasone RC254-282 Chemotherapy medicine.diagnostic_test business.industry leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magnetic resonance imaging atorvastatin medicine.disease Surgery leukemia encephalopathy Leukemia 030104 developmental biology Oncology chronic subdural hematoma business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
ISSN: | 2234-943X |
Popis: | We are not aware of any reports regarding conservative treatment for leukemia-related chronic subdural hematoma (CSDH). We report our experience with 3 men who were admitted with subdural masses and abnormal leukocyte counts. In two patients, leukemia and CSDH were confirmed on the basis of medical records, mild head trauma, and neuroimaging features. Both patients experienced reduced CSDH and neurological symptoms after receiving atorvastatin (20 mg/day) plus low-dose dexamethasone. However, this combined conservative treatment was ineffective in the third patient, who was diagnosed as having leukemia and showed an increased hematoma volume after two weeks of therapy. Magnetic resonance imaging findings suggested dural metastasis, which prompted a switch from statin-based conservative treatment to chemotherapy. Complete remission of the leukemia and resolution of the subdural mass were observed after chemotherapy, which supported a diagnosis of leukemia encephalopathy. The 5-month follow-ups did not reveal CSDH relapse in all 3 cases. Thus, atorvastatin-based conservative treatment may be effective for leukemia-related CSDH but not for leukemia encephalopathy. |
Databáze: | OpenAIRE |
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