Chemical kindling induced by pentylenetetrazol changes cholecystokinin mRNA and peptide levels in rat frontal cortex
| Autor: | Katsumichi Takeda, Kousuke Nakata, Tsugutaka Ito, Toshiyuki Chikuma, Takeshi Kato |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Hippocampus Neuropeptide digestive system Internal medicine Gene expression Kindling Neurologic medicine Animals RNA Messenger Rats Wistar Pentylenetetrazol Cholecystokinin Kindling Chemistry General Neuroscience Neuropeptides digestive oral and skin physiology Frontal Lobe Rats Endocrinology medicine.anatomical_structure Pentylenetetrazole Kindling model hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience Letters. 234:115-118 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(97)00677-0 |
| Popis: | Kindling model is useful to study the mechanism of learning and memory. Cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels in the hippocampus and frontal cortex of chemically kindled rats were determined at different time points. In the frontal cortex, chronic treatment with pentylenetetrazol (PTZ) (40 mg/kg per day for 8 days) increased CCK mRNA level at 7 days, and decreased CCK-LI level at 2 and 7 days after the last injection. However, neither CCK mRNA nor CCK-LI levels in the hippocampus changed. These results suggest that PTZ-induced kindling increases CCK mRNA expression and CCK-LI release in the frontal cortex. |
| Databáze: | OpenAIRE |
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