Conditioning with slowly digestible starch diets in mice reduces jejunal α-glucosidase activity and glucogenesis from a digestible starch feeding
| Autor: | Shaji Chacko, Like Y. Hasek, Roberto Quezada-Calvillo, Stephen E. Avery, J. Kenneth Fraley, Bruce R. Hamaker, Firoz A. Vohra, Buford L. Nichols |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Absorption (pharmacology) Starch Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Sucrase 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine medicine Animals Food science 030109 nutrition & dietetics Nutrition and Dietetics Chemistry food and beverages alpha-Glucosidases Small intestine Diet medicine.anatomical_structure Glucose Gluconeogenesis Conditioning Digestion Digestible starch |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 78 |
| ISSN: | 1873-1244 |
| Popis: | Objectives Maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) are mucosal α-glucosidases required for the digestion of starch to glucose. We hypothesized that a dietary approach to reduce Mgam and Si activities can reduce glucose generation and absorption, and improve glucose control. Methods Rice starch was entrapped in alginate microspheres to moderate in vitro digestion properties. Three groups of 8-wk old mice (n = 8) were conditioned for 7 d with low 13C-starch-based materials differing in digestion rates (fast, slow, and slower), and then given a digestible 13C-labeled cornstarch test feeding to determine its digestion to glucose. Results Conditioning of the small intestine with the slowly digestible starches for 7 d reduced jejunal α-glucosidase and sucrase activities, as well as glucose absorption for the slowly digestible starch slower group (P Conclusions Decreased glucogenesis from a digestible starch feeding was found in mice conditioned on slowly digestible starch diets, suggesting that a dietary approach incorporating slowly digestible starches may change α-glucosidase activities to moderate glucose absorption rate. |
| Databáze: | OpenAIRE |
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