Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements
| Autor: | Arda Kiani, Maryam Sadat Mirenayat, Esmaeil Mortaz, Ian M. Adcock, Atefeh Abedini, Mehdi Kazempour-Dizaji, Kimia Taghavi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Vitamin
Spirometry Biochemistry & Molecular Biology medicine.medical_specialty Pathology vitamin d (d 014807) 030204 cardiovascular system & hematology sarcoidosis (D012507) TUBERCULOSIS Gastroenterology vitamin D deficiency Pulmonary function testing hiperkalciurija (D053565) lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Hypercalciuria lcsh:QD415-436 MACROPHAGES General Clinical Medicine vitamin D (D014807) Original Paper hypercalciuria (D053565) Science & Technology Lung medicine.diagnostic_test business.industry medicine.disease medicine.anatomical_structure 030228 respiratory system chemistry sarkoidoza (D012507) Sarcoidosis business Life Sciences & Biomedicine |
| Zdroj: | Journal of Medical Biochemistry, Vol 37, Iss 2, Pp 103-109 (2018) Journal of Medical Biochemistry |
| ISSN: | 1452-8266 |
| Popis: | Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.Eighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.A significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.In conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2-4 of lung involvements.Uprkos negativnoj povezanosti između 25-hidroksi vitamina D i učestalosti brojnih hroničnih respiratornih oboljenja, ovaj uticaj još uvek nije ispitivan u sarkoidozi. Ova istraživanja izučavaju vezu između deficijencije 25-hidroksi vitamina D sa stepenom hroničnosti kod sarkoidoze, aktivnosti oboljenja, ekstra pulmonalnih kožnih manifestacija, nivoa kalcijuma u urinu i statusa pulmonalne funkcije kod Iranskih pacijenata sa sarkoidozom. Rezultati ovih izučavanja sa budućim istraživanjima mogu ukazati na mnogo bolji uspeh u tretmanu sarkoidoze.Proučavano je osamdeset pacijenata sa sarkoidozom podeljenih u dve grupe u odnosu na insuficijentni i zadovoljavajući nivo 25-hidroksi vitamina D. Stepen sarkoi doze je definisan kao akutna i hronična sarkoidoza. Pulmonalni fnkcionalni test (PFT) je izveden spirometrijom. Uključenost kože je definisana biopsijom. Nivo kalcijuma u 24-urinu je korišćen za dokazivanje stepena aktivnosti oboljenja. Stepen uključenosti promena na plućima je dobijen primenom CT-skenera i snimanjem pluća rendgenski. Za statističku procenu rezultata korišćen je statistički program Social Sciences (SPSS).Dobijena je značajno negativna korelacija između deficijencije vitamina D kod pacijenata sa sarkoidozom i hroničnog toka bolesti i stupnjeva u dva do četiri plućna stepena. Nije nađena značajna korelacija između drugih parametara oboljenja i deficijencije vitamina D.Može se zaključiti da dobijeni rezultati ukazuju na ulogu deficijencije vitamina 25(OH)D u predviđanju toka hronične sarkoidoze. Takođe, može se zaključiti da deficijencija vitamina 25(OH)D može ukazati na pulmonalnu sarkoidozu sa uključenjem pluća stepena 2–4. |
| Databáze: | OpenAIRE |
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