Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring

Autor: Sae Bom Won, Anna Han, Young Hye Kwon
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Offspring
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Genistein
Apoptosis
Biology
medicine.disease_cause
Biochemistry
Epigenesis
Genetic
Histones
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Lactation
Internal medicine
Gene expression
medicine
Animals
Epigenetics
Molecular Biology
Prenatal Nutritional Physiological Phenomena
Cell Proliferation
Fetus
Nutrition and Dietetics
TOR Serine-Threonine Kinases
Maternal Nutritional Physiological Phenomena
DNA Methylation
Isoflavones
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Gene Expression Regulation
Liver
030220 oncology & carcinogenesis
DNA methylation
Soybean Proteins
bacteria
Female
Carcinogenesis
Zdroj: The Journal of nutritional biochemistry. 42
ISSN: 1873-4847
Popis: In utero environment is known to affect fetal development. Especially, the distinct fetal programming of carcinogenesis was reported in offspring exposed to maternal diets containing soy protein isolate (SPI) or genistein. Therefore, we investigated whether maternal consumption of low-isoflavone SPI or genistein alters hepatic gene expression and liver development in rat offspring. Female Sprague-Dawley rats were fed a casein diet, a low-isoflavone SPI diet or a casein diet supplemented with genistein (250 mg/kg diet) for 2 weeks before mating and throughout pregnancy and lactation. Male offspring were studied on postnatal day 21 (CAS, SPI and GEN groups). Among 965 differentially expressed hepatic genes related to maternal diet (P
Databáze: OpenAIRE
Externí odkaz: