Potential mechanisms for redistribution of polychlorinated biphenyls during pregnancy and lactation
| Autor: | M. J. Vodicnik, L. A. Gallenberg |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Health Toxicology and Mutagenesis Mammary gland Adipose tissue Lipoproteins VLDL Biology Toxicology Biochemistry Mammary Glands Animal Pregnancy Lactation Internal medicine medicine Animals Tissue Distribution Triglycerides Pharmacology Lipoprotein lipase Hypertriglyceridemia Rats Inbred Strains Blood Proteins General Medicine medicine.disease Polychlorinated Biphenyls In vitro Rats Lipoproteins LDL Kinetics Endocrinology medicine.anatomical_structure Adipose Tissue Liver Pregnancy Animal Female lipids (amino acids peptides and proteins) |
| Zdroj: | Xenobiotica. 17:299-310 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498258709043940 |
| Popis: | Female mice treated with 14C-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) two weeks prior to mating eliminated virtually their entire body burden of the compound through milk during one lactation cycle. 6-CB was shown to distribute among rat and human plasma lipoproteins and protein in vitro. It was readily transferred among plasma constituents and its distribution was related to the triacylglycerol:protein ratio in plasma. At one hour following its intravenous administration to virgin rats, 6-CB was primarily distributed to LDL. With the hypertriglyceridemia of late pregnancy, more than 70% of circulating 6-CB was associated with VLDL. VLDL is a major substrate for mammary gland lipoprotein lipase which is elevated during lactation. When 6-CB was complexed with human VLDL and injected i.v. into late pregnant mice, mammary gland concentrations of 6-CB exceeded those of adipose tissue at all sacrifice times between 5 min and 6 h. No differences between adipose tissue and mammary gland concentrations of 6-CB were observed with Emulphor:ethanol:saline as vehicle until 6 h. Isolated hepatocytes were capable of secreting protein and triacylglycerol in the form of VLDL into serum-free media. Eighty percent of 6-CB released from hepatocytes was in association with VLDL, with the remainder in association with protein. Adipocytes isolated from epididymal fat pads of male rats which were pretreated with 6-CB released progressively less radioactivity to incubation media with time after treatment even though PCB content of these cells increased. 6-CB may not be evenly distributed among adipocyte lipids. |
| Databáze: | OpenAIRE |
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