PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer
| Autor: | Jiaying Lou, Hongxian Zhang, Huiyu Xu, Rong Li, Balázs Győrffy, Yong Han, Yue Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty muscle PDGFRA insulin-resistant 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Obstetrics and gynaecology Internal medicine medicine PCOS Pyruvate Metabolism obese business.industry Cancer Metabolic symptoms medicine.disease Obesity 030104 developmental biology 030220 oncology & carcinogenesis Biomarker (medicine) business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Huiyu Xu 1, * , Yong Han 2, * , Jiaying Lou 3 , Hongxian Zhang 4 , Yue Zhao 1 , Balazs Győrffy 5, 6 and Rong Li 1 1 Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, P.R. China 2 Department of Pathology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, P.R. China 3 Department of Clinical Laboratory, Renmin Hospital of Xiaoshan District, Hangzhou, Zhejiang Province, P.R. China 4 Department of Urology, Peking University Third Hospital, Beijing, P.R. China 5 Momentum Cancer Biomarker Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary 6 Second Department of Pediatrics, Semmelweis University, Budapest, Hungary * These authors have contributed equally to this work Correspondence to: Rong Li, email: roseli001@sina.com Keywords: PCOS, obese, insulin-resistant, muscle, breast cancer Received: June 30, 2016 Accepted: April 26, 2017 Published: May 13, 2017 ABSTRACT To explore the key genes associated with both PCOS and breast cancer, we overlapped the synchronously differently expressed genes in two obese insulin-resistant GEO datasets in muscle tissue and genes exert essential roles in breast cancer prognosis together base on the following reasons: (1) Androgens excess is believed to contribute to the onset of both PCOS and breast cancer. (2) PCOS is usually complicated with metabolic symptoms, such as obesity and insulin-resistance. (3) Muscle is the main place where energy metabolism and material metabolism take place. Consequently, 53 genes were found, functionally enriched in pathways such as pyruvate metabolism, muscle system process and development of primary male sexual characteristics etc. We further lay our eyes on genes correlated with male sexual characteristics, which may be involved in the onset of both PCOS and breast cancer. Three genes were indicated to be associated with this process, including hydroxysteroid (17-beta) dehydrogenase 4/HSD17B4, platelet-derived growth factor receptor, alpha polypeptide/PDGFRA and high-mobility group box 2/HMGB2. Gene-drug interaction network about the three genes were then constructed. Drugs or chemicals that contribute to correcting the disorder of lipid metabolism were detected to restore the abnormal expression of the three genes in PCOS, such as simvastatin, bezafibrate, fenofibrate et al, which provide further choices for managing patients with PCOS. |
| Databáze: | OpenAIRE |
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