Unusual cause of flare in antineutrophil cytoplasmic antibody-associated vasculitis
| Autor: | Henry Penn, James Robert William Glanville |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
medicine.medical_specialty Prednisolone media_common.quotation_subject Antidotes Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 030204 cardiovascular system & hematology Article Mycophenolic acid Antibodies Antineutrophil Cytoplasmic 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Humans Drug Interactions 030212 general & internal medicine Her Disease media_common Anti-neutrophil cytoplasmic antibody Treatment regimen business.industry General Medicine Middle Aged Mycophenolic Acid medicine.disease Absorption Physicochemical Charcoal Female Vasculitis business Immunosuppressive Agents medicine.drug |
| Zdroj: | BMJ Case Reports. :bcr2015213687 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2015-213687 |
| Popis: | A 53-year-old woman attended for a routine outpatient appointment for follow-up of antineutrophil cytoplasmic antibody-positive vasculitis. Her disease had relapsed despite appropriate medical management with mycophenolate mofetil (MMF), as evidenced by rising acute phase response and antimyeloperoxidase titre with ongoing symptoms. On further questioning, she had been taking oral charcoal as part of a detoxification diet, which we postulate was causing significantly impaired MMF absorption. This case report summarises the presentation and highlights the importance of a thorough drug history, and should prompt the reader to keep an open mind with regard to drug interactions and treatment regimen adherence when treatment is, unexpectedly, seemingly failing. |
| Databáze: | OpenAIRE |
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