Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression
| Autor: | Tantip Boonsong, Wachirawadee Malakul, Wanwisa Deenin, Ittipon Phoungpetchara, Sakara Tunsophon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Inflammation Disease medicine.disease_cause Lipogenic gene expression 03 medical and health sciences 0302 clinical medicine Internal medicine Gene expression medicine Obesity Hepatology business.industry High fat diet digestive oral and skin physiology Fatty liver food and beverages nutritional and metabolic diseases Non alcoholic Basic Study medicine.disease Endocrinology Oxidative stress Papaya 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology medicine.symptom business Non-alcoholic fatty liver disease |
| Zdroj: | World Journal of Hepatology |
| ISSN: | 1948-5182 |
| DOI: | 10.4254/wjh.v13.i3.315 |
| Popis: | BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a global health issue that is correlated with obesity and oxidative stress. AIM To evaluate the anti-NAFLD effect of papaya in high fat diet induced obesity in rats. METHODS Four-week-old male Sprague-Dawley rats were divided into four groups after 1 wk of acclimatization: Group 1 was the rats fed a normal diet (C); group 2 was the rats fed a high fat diet (HFD); group 3 was the rats fed a HFD with 0.5 mL of papaya juice/100 g body weight (HFL), and group 4 was the rats fed a HFD with 1 mL of papaya juice/100 g body weight (HFH) for 12 wk. At the end of the treatment, blood and tissue samples were collected for biochemical analyses and histological assessment. RESULTS The results of the HFH group showed significantly reduced body weight (HFH vs HFD, P < 0.01), decreased NAFLD score (HFH vs HFD, P < 0.05), and reduced hepatic total cholesterol (HFL vs HFD, P < 0.01; HFH vs HFD, P < 0.001), hepatic triglyceride (HFH vs HFD, P < 0.05), malondialdehyde (HFL, HFH vs HFD, P < 0.001), tumour necrosis factor-α (HFH vs HFD, P < 0.05) and interleukin-6 (HFH vs HFD, P < 0.05) when compared to the HFD group. However, the liver weight showed no significant difference among the groups. The activities of catalase and superoxide dismutase significantly increased in HFH when compared with the HFD group (P < 0.05 and P < 0.001, respectively). The suppression of transcriptional factors of hepatic lipogenesis, including sterol regulatory element-binding protein 1c and fatty acid synthase, were observed in the papaya treated group (HFH vs HFD, P < 0.05). These beneficial effects of papaya against HFD-induced NAFLD are through lowering hepatic lipid accumulation, suppressing the lipogenic pathway, improving the balance of antioxidant status, and lowering systemic inflammation. CONCLUSION These current results provide experimental-based evidence suggesting papaya is an efficacious medicinal fruit for use in the prevention or treatment of NAFLD. |
| Databáze: | OpenAIRE |
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