Detection of the latency-associated transcript in neuronal cultures during the latent infection with herpes simplex virus type 1
| Autor: | Lewis I. Pizer, Christine L. Wilcox, Christian Doerig |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Gene Expression Regulation
Viral Transcription Genetic viruses Ubiquitin-Protein Ligases Biology medicine.disease_cause Immediate early protein Herpesviridae Virus Immediate-Early Proteins Viral Proteins Virology Gene expression medicine Humans Simplexvirus RNA Messenger Cells Cultured Neurons Messenger RNA Herpes Simplex Molecular biology Herpes simplex virus Nerve growth factor nervous system Cell culture Virus Activation |
| Zdroj: | Virology. 183(1) |
| ISSN: | 0042-6822 |
| Popis: | The transcriptional studies reported in this paper indicate that the latency-associated transcript (LAT) is present in neuronal cultures during the latent infection with herpes simplex virus type 1 (HSV-1). During the latent infection glycoprotein D (gD) mRNA, a mRNA characteristic of the productive infection, is not detected. However, following reactivation by nerve growth factor (NGF) deprivation, gD mRNA is detected in the neuronal cultures. Thus, the restricted viral gene expression in the in vitro neuronal model indicates that the latent infection in culture is analogous to that observed in vivo. |
| Databáze: | OpenAIRE |
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