Publisher Correction: Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
| Autor: | Peter J. M. Openshaw, Jeroen Aerssens, Daniel H. O'Connor, Harish Nair, Federico Martinón-Torres, Christopher C Butler, Simon B. Drysdale, Matthew D. Snape, Tanya Golubchik, David Bonsall, Rory Bowden, Deniz Öner, Anthony Brown, G MacIntyre-Cockett, M A Ansari, E Mellado-Gomez, Andrew J. Pollard, M de Cesare, Louis Bont, Lin G-L. |
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| Přispěvatelé: | Commission of the European Communities |
| Rok vydání: | 2021 |
| Předmět: |
Male
GeneralLiterature_INTRODUCTORYANDSURVEY Science Mutation Missense General Physics and Astronomy Respiratory Syncytial Virus Infections Biology Virus Replication Viral infection General Biochemistry Genetics and Molecular Biology Virus Viral Proteins Viral genetics Humans Viral evolution Aged Science & Technology Multidisciplinary Host (biology) Genetic Variation Infant General Chemistry Publisher Correction Antigenic Variation Virology Multidisciplinary Sciences Respiratory Syncytial Virus Human ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Science & Technology - Other Topics Female RESCEU Investigators |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups. |
| Databáze: | OpenAIRE |
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