A Decrease in the Immunoglobulin G Antibody Response against the VlsE Protein of Borrelia burgdorferi Sensu Lato Correlates with the Resolution of Clinical Signs in Antibiotic-Treated Patients with Early Lyme Disease
| Autor: | Roberto Cevenini, Silvia Accardo, Vittorio Sambri, Valeria Mondardini, Alessandra Moroni, Francesca Cavrini, Elisa Storni, Antonella Marangoni |
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| Přispěvatelé: | Marangoni A., Sambri V., Accardo S., Cavrini F., Mondardini V., Moroni A., Storni E., Cevenini R. |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) Time Factors Lipoproteins Clinical Biochemistry Immunology Biology DIAGNOSIS THERAPY Immunoglobulin G Lyme disease Bacterial Proteins Antigen Borrelia medicine Humans Immunology and Allergy Borrelia burgdorferi Aged Retrospective Studies Immunosuppression Therapy Antigens Bacterial Lyme Disease Antibody titer Early Localized Lyme Disease Middle Aged medicine.disease biology.organism_classification Antibodies Bacterial Anti-Bacterial Agents biology.protein VLSE PROTEIN ANTIBODY RESPONSE Female Microbial Immunology Antibody |
| Zdroj: | Clinical and Vaccine Immunology. 13:525-529 |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.13.4.525-529.2006 |
| Popis: | The purpose of this study was to evaluate the diagnostic performance of the LIAISON Borrelia Screen (Diasorin, Saluggia, Italy), a new automated immunoassay based on the chemiluminescent technology (chemiluminescence immunoassay). To assess whether a decrease in a negative value in the anti-VlsE immunoglobulin G (IgG) antibody titer was correlated with a positive response to treatment, a group of serially collected serum samples from 67 patients with culture-confirmed erythema migrans was retrospectively studied. All the patients had been treated with antibiotics and were free of disease within 3 to 6 months of follow-up. All the 15 patients who were found to be IgG positive at the time of enrollment and who were bled at least four times during the follow-up became IgG seronegative at 2 to 6 months posttreatment. These results indicate that a decline in the anti-VlsE antibody titer coincides with effective antimicrobial therapy in patients with early localized Lyme disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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