Autonomic, EEG, and Behavioral Arousal Signs in a PVS Case After Zolpidem Intake
| Autor: | Jesús Pérez-Nellar, Rafael Rodríguez, Calixto Machado, Joel Gutierrez, Liana Portela, Carlos Beltrán, Maylen Carballo, Maria C. Garcia-Roca, Mauricio Chinchilla, Mario Estévez, Andrés Machado |
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| Rok vydání: | 2011 |
| Předmět: |
Agonist
Zolpidem Pyridines medicine.drug_class Nonbenzodiazepine Blood Pressure Electroencephalography Autonomic Nervous System Arousal Young Adult Heart Rate Humans Medicine Heart rate variability medicine.diagnostic_test business.industry GABAA receptor Persistent Vegetative State Spectrum Analysis Minimally conscious state General Medicine medicine.disease Brain Waves Neurology Anesthesia cardiovascular system Female Neurology (clinical) business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2057-0155 0317-1671 |
| DOI: | 10.1017/s0317167100011562 |
| Popis: | the paradoxical “arousing” effect of Zolpidem, a highly selective nonbenzodiazepine gamma aminobutyric acid (GABA) agonist acting on the [omega]-1 site of the GABA A receptor, in persistent vegetative state (PVS), in minimally conscious state (MCS) patients, ischemic stroke cases, after brain injury, and in patients suffering hypoxic encephalopathy.1 We describe here this paradoxical arousing effect in a PVS case assessing autonomic, electroencephalographic (EEG), and behavioral changes, after Zolpidem uptake. This case report is the first to show the importance of using heart rate variability (HRV) methodology and EEG to assess autonomic and brain functional changes in a PVS case, during this pharmacological intervention. |
| Databáze: | OpenAIRE |
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