Hidden diagnosis of multiple endocrine neoplasia-1 unraveled during workup of virilization caused by adrenocortical carcinoma
| Autor: | N Kannan, Abhay Gundgurthi, Aditi Pandit, Sandeep Kharb, Reena Bharwaj, K. S. Brar, M K Garg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities endocrine system Adrenocortical carcinoma endocrine system diseases Endocrinology Diabetes and Metabolism Cushing's syndrome Case Report Neuroendocrine tumors lcsh:Diseases of the endocrine glands. Clinical endocrinology Endocrinology medicine Carcinoma multiple endocrine neoplasia-1 Adrenal adenoma Endocrine system Cushing′s syndrome MEN1 lcsh:RC799-869 lcsh:RC648-665 business.industry Virilization virilizing syndrome medicine.disease medicine.anatomical_structure lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom Pancreas business |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 3, Pp 514-518 (2013) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Multiple endocrine neoplasia-1 (MEN1) is an autosomal dominant syndrome with classic triad of parathyroid hyperplasia, pancreatic neuroendocrine tumors, and pituitary adenomas. Other recognized manifestations include carcinoid, cutaneous or adrenocortical tumors. It is commonly presented with clinical features related to parathyroid, pancreas or pituitary lesions. Here, we have presented a case that had virilization and biochemical Cushing's syndrome due to adrenocortical carcinoma as presenting feature of MEN1. Cushing's syndrome in MEN1 is an extremely rare and usually late manifestation and most cases are due to corticotropin-producing pituitary adenomas. Although Cushing's syndrome generally develops years after the more typical manifestations of MEN1 appear, it may be the primary manifestation of MEN1 syndrome particularly when related to adrenal adenoma or carcinoma. |
| Databáze: | OpenAIRE |
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