Biomarkers associated with periodontitis and peri-implantitis: a systematic review
| Autor: | Haralampos Petridis, Federico Moreno, Amardip Singh Kalsi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Peri-implantitis 0206 medical engineering 02 engineering and technology Disease Review Secondary care 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Periodontitis business.industry 030206 dentistry medicine.disease University hospital 020601 biomedical engineering Etiology Periodontics Biomarker (medicine) Cytokines Observational study Oral Surgery business Implant Science Biomarkers |
| Zdroj: | Journal of Periodontal & Implant Science |
| ISSN: | 2093-2286 2093-2278 |
| Popis: | Purpose The pathology of peri-implantitis is still not fully understood and there have been recent challenges to the consensus on its aetiology and pathology, especially in comparison with periodontitis. The assessment of biomarkers allows a comparison of the pathology of these diseases. The aim of this systematic review was to answer the research question: “Is there a difference in the biomarkers associated with peri-implantitis compared with periodontitis in adult humans?” Methods Electronic databases were searched and screened, and a manual search was also undertaken. The inclusion criteria were adults with peri-implantitis who had been compared to adults with periodontitis with the outcome of biomarkers assessed via biopsies or crevicular fluid samples in primary or secondary care settings, as recorded in case-control, case series and retrospective, prospective and cross-sectional observational studies. Two reviewers independently screened titles and abstracts and assessed full text articles for eligibility and inclusion. Both reviewers independently extracted data and assessed risk of bias. Differences in biomarker levels were the primary outcome and a narrative review was undertaken due to the heterogeneity of studies. Results In total, 2,374 articles were identified in the search, of which 111 full-text articles were assessed for eligibility and 13 were included in the qualitative synthesis. Five of the 13 included studies were deemed to be at high risk of bias, with the others having moderate risk. All studies were cross-sectional and performed at university hospitals. Nine of the 13 included studies found significant differences in the levels of biomarkers or their ratios between peri-implantitis and periodontitis. Four of the studies found no significant differences. Conclusions Within the limitations of the included studies, it appears that there may be a difference in biomarker levels and ratios between peri-implantitis and periodontitis, suggesting that these disease processes are somewhat distinct. Graphical Abstract |
| Databáze: | OpenAIRE |
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