A European outbreak of Salmonella enterica serotype Typhimurium definitive phage type 204b in 2000
| Autor: | J.F. Aguilera, G Sigmundsdottir, J Cowden, Helmut Tschäpe, Sarah J. O'Brien, E.J. Threlfall, Marc-Alain Widdowson, Linda R. Ward, P.D. Crook, H. Briem, Ian Fisher, A. Amnion, Deborah Wilson, M.E. Locking, W van Pelt |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Serotype Adult Male Salmonella typhimurium medicine.medical_specialty Salmonella Veterinary medicine Adolescent food-borne medicine.disease_cause Disease Outbreaks Antibiotic resistance Environmental health Epidemiology Drug Resistance Bacterial medicine Humans antimicrobial resistance Typing Serotyping Child international outbreak Bacteriophage Typing Aged Aged 80 and over Communicable disease biology business.industry Infant Newborn Outbreak Infant General Medicine Middle Aged biology.organism_classification Infectious Diseases Salmonella enterica Child Preschool Salmonella Infections surveillance Female business |
| Zdroj: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 9(8) |
| ISSN: | 1198-743X |
| Popis: | Objective To describe the clinical, epidemiologic and microbiological features of a large outbreak of infection with a multiresistant Salmonella enterica serotype Typhimurium definitive type DT204b infection involving at least 392 people in five European countries. Methods Icelandic public-health doctors responded to a report on an Internet news site of an outbreak of infection with a multiresistant strain of Typhimurium DT104 in England by contacting the Public Health Laboratory Service (PHLS) Communicable Disease Surveillance Centre (CDSC). An international alert was sent out through Enter-net. All strains from England & Wales, The Netherlands, Scotland and Germany, and 17 of the outbreak isolates from Iceland, were phage-typed, screened for antimicrobial resistance, and subjected to molecular typing. Hypothesis-generating interviews were conducted, followed by case–control studies performed in Iceland and England. Results Isolates from cases in Iceland, England and Wales, The Netherlands, Scotland and Germany were identified as Typhimurium DT204b. The antimicrobial resistance pattern was ACGNeKSSuTTmNxCp L . All strains tested displayed an identical plasmid profile. Strains from five cases in England & Wales and five cases in Iceland possessed identical pulsed-field profiles. Although a common source was suspected, only Iceland implicated imported lettuce as a vehicle, with an analytic epidemiologic study (OR = 40.8; P = 0.005; 95% CI 2.7–3175). Conclusion The identification of international outbreaks, necessary for investigation and control, can be facilitated by standardized phage-typing techniques, the electronic transfer of molecular typing patterns, formal and informal links established through international surveillance networks, and the early reporting of national outbreaks to such networks. |
| Databáze: | OpenAIRE |
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