Tangeretin inhibits fungal ferroptosis to suppress rice blast
| Autor: | Meiling Liang, Qing Shen, Wenxiang Gu, Yi Zhen Deng, Naweed I. Naqvi, Guobing Cui, Huijuan Ye, Xianya Jiang, Lian-Hui Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
Antioxidant medicine.medical_treatment Flavonoid Plant Science Biology Biochemistry General Biochemistry Genetics and Molecular Biology Microbiology Lipid peroxidation Fungal Proteins Tangeretin chemistry.chemical_compound medicine Ferroptosis Plant Diseases chemistry.chemical_classification Appressorium Reactive oxygen species fungi food and beverages Oryza Flavones Magnaporthe chemistry NOX1 |
| Zdroj: | Journal of integrative plant biologyREFERENCES. 63(12) |
| ISSN: | 1744-7909 |
| Popis: | Flavonoids are polyphenolic secondary metabolites that function as signaling molecules, allopathic compounds, phytoalexins, detoxifying agents and antimicrobial defensive compounds in plants. Blast caused by the fungus Magnaporthe oryzae is a serious disease affecting rice cultivation. In this study, we revealed that a natural flavonoid, tangeretin, substantially delays the formation of M. oryzae appressoria and blocks the development of blast lesions on rice plants. Our data suggest that tangeretin has antioxidant activity that interferes with conidial cell death/ferroptosis, which is critical for M. oryzae pathogenicity. Tangeretin showed a comparable inhibition capacity and efficacy to those of the well-established ferroptosis inhibitor liproxstatin-1. Furthermore, overexpression of the NADPH oxidases NOX1 or NOX2 significantly decreased sensitivity towards tangeretin treatment, suggesting Nox-mediated lipid peroxidation as a possible target for tangeretin in regulating redox signaling and ferroptosis in M. oryzae. Our nursery and field tests showed that application of tangeretin can effectively mitigate overall disease symptoms and prevent leaf blast. Our study reveals the plant-derived fungal ferroptosis inhibitor tangeretin as a potential and novel antifungal agrochemical for the sustainable prevention of the devastating blast disease in important cereal crops. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |