Effects of some cholinergic agonists on neocortical slow wave activity in rats with basal forebrain lesions
| Autor: | Angela Raithby, Carolina Cristi, C.H. Vanderwolf, Melissa Snider, Carolyn Tanner |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Kainic acid Arecoline Scopolamine Derivatives Body Temperature chemistry.chemical_compound Prosencephalon Internal medicine medicine Oxotremorine Animals Cerebral Cortex Basal forebrain Kainic Acid Neocortex Dose-Response Relationship Drug General Neuroscience Pilocarpine Brain Parasympatholytics Electroencephalography N-Methylscopolamine Rats Endocrinology medicine.anatomical_structure Parasympathomimetics nervous system chemistry Cerebral cortex Tacrine Cholinergic Neuroscience medicine.drug |
| Zdroj: | Brain Research Bulletin. 31:515-521 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(93)90118-u |
| Popis: | Chronic rats, prepared with unilateral injections of kainic acid in the left basal forebrain, displayed prominent large amplitude slow wave activity in the neocortex ipsilateral to the injection. Oxotremorine and pilocarpine, given systemically following pretreatment with methyl scopolamine to block peripheral muscarinic effects, restored low voltage fast activity (LVFA) in a dose-related manner. Oxotremorine was more potent than pilocarpine. Arecoline was not consistently effective. Tetrahydroaminoacridine abolished abnormal 4–6 Hz rhythmical slow waves in the left neocortex but had little effect on large amplitude irregular slow waves. Direct-acting cholinergic agonists can restore near-normal neocortical activity after extensive cholinergic deafferentation of the neocortex. |
| Databáze: | OpenAIRE |
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