Terbutaline Accumulates in Blood and Urine after Daily Therapeutic Inhalation
| Autor: | Yvette Dehnes, Anders Dyreborg, Peter Hemmersbach, Vibeke Backer, Morten Hostrup, Sebastian Rzeppa, Nanna Krogh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Terbutaline Cmax Physical Therapy Sports Therapy and Rehabilitation Urine 01 natural sciences Drug Administration Schedule Excretion 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Administration Inhalation medicine Humans Orthopedics and Sports Medicine Exercise physiology Exercise Inhalation business.industry 010401 analytical chemistry VO2 max 030229 sport sciences Bronchodilator Agents 0104 chemical sciences Area Under Curve Anesthesia business medicine.drug |
| Zdroj: | Medicine & Science in Sports & Exercise. 49:1236-1243 |
| ISSN: | 0195-9131 |
| DOI: | 10.1249/mss.0000000000001199 |
| Popis: | This study investigated pharmacokinetics of terbutaline after single and seven consecutive days of inhalation in exercising trained men. Twelve healthy young trained men underwent two pharmacokinetic trials comparing single dose (2 mg) and seven consecutive days (2 mg×d-1) of inhaled terbutaline. After inhalation of terbutaline at each trial, subjects performed 90 min of bike ergometer exercise at 65% of maximal oxygen consumption after which they stayed inactive. Blood and urine samples were collected before and after inhalation of terbutaline. Samples were analyzed by high performance liquid chromatography–tandem mass spectrometry. Maximum serum concentration of terbutaline (Cmax) (6.4 (±1.2) vs. 4.9 (±1.2) ng×mL-1, P = 0.01) (mean (±95% confidence interval)) and area under serum concentration-time curve from 0 to 4 hours after inhalation (AUC0-4) (16 (±3) vs. 13 (±2) ng×mL-1×h, P ≤ 0.005) were higher after seven days of inhalation compared to the first day. Seven days of terbutaline inhalation resulted in accumulation of terbutaline in urine, in which total urine excretion of terbutaline was higher after seven days of inhalation compared to the first day (274 ± (43) vs. 194 (±33) μg, P ≤ 0.001). These differences were partly attributed to systemic accumulation of terbutaline after consecutive days of inhalation, in that baseline serum and urine samples revealed incomplete elimination of terbutaline. Terbutaline accumulates in serum and urine after consecutive days of inhalation. For doping control purposes, these observations are of relevance if a urine threshold and decision limit is to be introduced for terbutaline on the World Anti-Doping Agency’s list of prohibited substances, since asthmatic athletes may use their bronchorelievers for consecutive days. |
| Databáze: | OpenAIRE |
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