Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex
| Autor: | Crésio Alves, Maria Betânia Pereira Toralles, Thaisa Souza, Carlos Brites, Isadora Meyer |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Hla genes lcsh:QR1-502 Immunogenetics Human leukocyte antigen Major histocompatibility complex infectious diseases Communicable Diseases lcsh:Microbiology lcsh:Infectious and parasitic diseases Major Histocompatibility Complex Immune system HLA Antigens Parasitic Diseases Humans lcsh:RC109-216 Allele Alleles Genetics biology Bacterial Infections major histocompatibility complex HLA Genetic marker Virus Diseases Immunology biology.protein Identification (biology) |
| Zdroj: | Brazilian Journal of Infectious Diseases v.10 n.2 2006 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 10, Issue: 2, Pages: 122-131, Published: APR 2006 Brazilian Journal of Infectious Diseases, Vol 10, Iss 2, Pp 122-131 |
| ISSN: | 1413-8670 |
| Popis: | Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surface-specific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians, which hampers the understanding of the association between the HLA system and diseases. We revised relevant studies on the association of HLA genes with infectious diseases, demonstrating their importance in the pathogenic mechanisms, through increased susceptibility or protection against infections and their complications. |
| Databáze: | OpenAIRE |
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