Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
| Autor: | Tomonori Okamura, Aya Kadota, Takumi Hirata, Miki Nozawa, Kazuyo Kuwabara, Mizuki Sata, Kuniko Kawamura, Hiroko Hattori, Naomi Miyamatsu, Yoko Nishida, Yoshihiro Miyamoto, Daisuke Sugiyama, Aya Hirata, Sachimi Kubo, Yoshimi Kubota, Aya Higashiyama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Urban Population Health Toxicology and Mutagenesis Urinary system Urology lcsh:Medicine Renal function urinary sodium 030204 cardiovascular system & hematology Kidney Logistic regression urinary sodium-potassium ratio Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Japan Risk Factors medicine Humans 030212 general & internal medicine Renal Insufficiency Chronic Aged business.industry Sodium renal function lcsh:R Public Health Environmental and Occupational Health Odds ratio Middle Aged medicine.disease Confidence interval Quartile estimated GFR Disease Progression Potassium Female business Dyslipidemia Glomerular Filtration Rate Kidney disease |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 5811, p 5811 (2020) International Journal of Environmental Research and Public Health Volume 17 Issue 16 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17165811 |
| Popis: | The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61&ndash 1.51), 1.06 (0.67&ndash 1.66), and 1.65 (1.06&ndash 2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage. |
| Databáze: | OpenAIRE |
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