Low molecular weight advanced glycation end products predict mortality in asymptomatic patients receiving chronic haemodialysis
| Autor: | Merlin C. Thomas, David A. Power, Neil Macmillan, Dharsh Fernando, Francesco L. Ierino, Matthew A Roberts |
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| Rok vydání: | 2006 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty medicine.medical_treatment Gastroenterology Asymptomatic Fluorescence Predictive Value of Tests Renal Dialysis Internal medicine medicine Humans Prospective Studies Mortality Prospective cohort study Aged Transplantation Receiver operating characteristic business.industry Hazard ratio Middle Aged medicine.disease Surgery Molecular Weight ROC Curve Cardiovascular Diseases Nephrology Predictive value of tests Kidney Failure Chronic Female Hemodialysis medicine.symptom business Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 21:1611-1617 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Background Advanced glycation end products (AGEs) have biological properties that may contribute to the premature cardiovascular mortality of haemodialysis patients. This study examines the hypothesis that low molecular weight forms of fluorescent AGEs (LMW fluorescence) predict mortality in haemodialysis patients. Methods The LMW fluorescence was measured in 85 patients treated with chronic haemodialysis and prospectively followed for 4 years. The primary outcome of all-cause mortality was assessed using Cox proportional hazards regression model. Results At the end of the follow-up period 37 (44%) patients died. The median LMW fluorescence level was 24.2 arbitrary units (range: 10.6-148.1 AU) and the receiver operator characteristic (ROC) curve cut-off for mortality was 37.0 AU. The LMW fluorescence predicted death both as a binary variable at the ROC cut-off, and as a continuous log-transformed variable when adjusted for age, albumin and C-reactive protein (CRP). Adjusted for age, albumin and CRP, the hazard ratio for mortality was 3.05 (1.41-6.60, P = 0.005) for LMW fluorescence as a binary variable and 2.71 per log unit (1.37-5.38, P = 0.004) as a continuous log-transformed variable. Conclusion The low molecular weight forms of AGEs predict mortality in patients receiving chronic haemodialysis, and may be important in the mechanisms leading to atherosclerosis and inflammation in such patients. |
| Databáze: | OpenAIRE |
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