Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Autor: Marín Franco, José Luis, Genoula, Melanie, Corral, Dan, Duette, Gabriel, Ferreyra, Malena, Maio, Mariano, Dolotowicz, María Belén, Aparicio-Trejo, Omar Emiliano, Patiño-Martínez, Eduardo, Charton, Alison, Métais, Arnaud, Fuentes, Federico, Soldan, Vanessa, Moraña, Eduardo José, Palmero, Domingo, Ostrowski, Matías, Schierloh, Pablo, Sánchez-Torres, Carmen, Hernández-Pando, Rogelio, Pedraza-Chaverri, José, Rombouts, Yoann, Hudrisier, Denis, Layre, Emilie, Vérollet, Christel, Maridonneau-Parini, Isabelle, Neyrolles, Olivier, Sasiain, María del Carmen, Lugo-Villarino, Geanncarlo, Balboa, Luciana, Benet, Susana, Gálvez, Cristina, Drobniewski, Francis, Kontsevaya, Irina, Arias, Lilibeth, Monguió‐Tortajada, Marta, Erkizia, Itziar, Urrea, Victor, Ong, Ruo‐Yan, Luquin, Marina, Dupont, Maeva, Chojnacki, Jakub, Dalmau, Judith, Cardona, Paula, Lugo‐Villarino, Geanncarlo, Julián, Esther, Furrer, Hansjakob, Günthard, Huldrych, Crocker, Paul, Tapia, Gustavo, Borràs, Francesc, Fellay, Jacques, McLaren, Paul, Telenti, Amalio, Cardona, Pere‐Joan, Clotet, Bonaventura, Vilaplana, Cristina, Martinez‐Picado, Javier, Izquierdo‐Useros, Nuria
Přispěvatelé: Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Wellcome Trust, Imperial College Trust, Commission of the European Communities
Jazyk: angličtina
Předmět:
Zdroj: Journal of extracellular vesicles, vol. 10, no. 3, pp. e12046
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Taylor & Francis, 2021, 10 (3), pp.108547. ⟨10.1002/jev2.12046⟩
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Benet, Susana; Gálvez, Cristina; Drobniewski, Francis; Kontsevaya, Irina; Arias, Lilibeth; Monguió-Tortajada, Marta; Erkizia, Itziar; Urrea, Victor; Ong, Ruo-Yan; Luquin, Marina; Dupont, Maeva; Chojnacki, Jakub; Dalmau, Judith; Cardona, Paula; Neyrolles, Olivier; Lugo-Villarino, Geanncarlo; Vérollet, Christel; Julián, Esther; Furrer, Hansjakob; Günthard, Huldrych F; ... (2021). Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles. Journal of extracellular vesicles, 10(3), e12046. Taylor & Francis 10.1002/jev2.12046
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 2001-3078
DOI: 10.1002/jev2.12046
Popis: The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non‐functional variant in SIGLEC1, which encodes the myeloid‐cell receptor Siglec‐1/CD169 implicated in HIV‐1 cell‐to‐cell transmission. Here we report a significant association between the SIGLEC1 null variant and extrapulmonary dissemination of Mycobacterium tuberculosis (Mtb) in two clinical cohorts comprising 6,256 individuals. Local spread of bacteria within the lung is apparent in Mtb‐infected Siglec‐1 knockout mice which, despite having similar bacterial load, developed more extensive lesions compared to wild type mice. We find that Siglec‐1 is necessary to induce antigen presentation through extracellular vesicle uptake. We postulate that lack of Siglec‐1 delays the onset of protective immunity against Mtb by limiting antigen exchange via extracellular vesicles, allowing for an early local spread of mycobacteria that increases the risk for extrapulmonary dissemination.
Databáze: OpenAIRE
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