Apolipoprotein E and intellectual achievement

Autor: Neill R. Graff-Radford, Richard J. Caselli, David Osborne, Eric M. Reiman, Ann M. Saunders, Carolyn J. Barbieri, John Hardy, Joseph G. Hentz, Gene E. Alexander, Geri Richards Hall
Rok vydání: 2002
Předmět:
Zdroj: Journal of the American Geriatrics Society. 50(1)
ISSN: 0002-8614
Popis: Objectives To determine whether apolipoprotein E (apo E) genotype influences intellectual achievement in cognitively normal individuals. Design Between 1994 and 1999 we performed apo E testing on 1,000 self-described cognitively normal residents of Maricopa County and detailed neuropsychological testing on a subset of 250. Setting Tertiary care academic medical center. Participants Cognitively normal adults genotyped for apo E. Measurements Measures of intellectual background included years of education and a demographically based estimate of intellectual capacity (demographic intellectual quotient (DIQ)). Measures of intellectual achievement, which included Wechsler Adult Intelligence Scale revised (WAIS-R), information (WAISI), and vocabulary (WAISV) scores, occupational intellectual requirements (OIR), and census-derived estimates of household income, were compared between apo E genetic subgroups while adjusting for intellectual background and demographic variables. Results WAISI, WAISV, OIR, and income correlated with age, sex, education, and DIQ, but after controlling for these variables there were no clinically significant differences between apo E-e4 homozygotes and noncarriers on any measure. Conclusions No clinically significant differences between genotypes were observed for the effects of education and DIQ on WAISI, WAISV, OIR, or income, although a larger sample size would be required to exclude smaller, clinically insignificant differences.
Databáze: OpenAIRE
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