Complete prevention of blood loss with self-sealing haemostatic needles
| Autor: | Seok Song Oh, Eui-Cheol Shin, Seon-Hui Hong, Sun-Woong Kang, Byung-Chang Oh, Ki-Suk Kim, Haeshin Lee, Moon Sue Lee, Keumyeon Kim, Mikyung Shin, Sung-Gurl Park, Seongyeon Jo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Hemorrhage Punctures 02 engineering and technology Hemophilia A 010402 general chemistry 01 natural sciences Mice Coated Materials Biocompatible Blood loss Animals Medicine General Materials Science Syringe Mice Inbred BALB C business.industry Mechanical Engineering Equipment Design General Chemistry Penetration (firestop) 021001 nanoscience & nanotechnology Condensed Matter Physics Hemostasis Surgical 0104 chemical sciences Surgery Equipment Failure Analysis Clinical Practice Needles Mechanics of Materials Injections Intravenous 0210 nano-technology business |
| Zdroj: | Nature Materials. 16:147-152 |
| ISSN: | 1476-4660 1476-1122 |
| DOI: | 10.1038/nmat4758 |
| Popis: | Bleeding is largely unavoidable following syringe needle puncture of biological tissues and, while inconvenient, this typically causes little or no harm in healthy individuals. However, there are certain circumstances where syringe injections can have more significant side effects, such as uncontrolled bleeding in those with haemophilia, coagulopathy, or the transmission of infectious diseases through contaminated blood. Herein, we present a haemostatic hypodermic needle able to prevent bleeding following tissue puncture. The surface of the needle is coated with partially crosslinked catechol-functionalized chitosan that undergoes a solid-to-gel phase transition in situ to seal punctured tissues. Testing the capabilities of these haemostatic needles, we report complete prevention of blood loss following intravenous and intramuscular injections in animal models, and 100% survival in haemophiliac mice following syringe puncture of the jugular vein. Such self-sealing haemostatic needles and adhesive coatings may therefore help to prevent complications associated with bleeding in more clinical settings. |
| Databáze: | OpenAIRE |
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