Swallowing Function Following Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Carcinoma: A 2-Year Follow-up
| Autor: | Daniel Gorelik, Arjun S. Joshi, Hannah R. Crowder, Nader Sadeghi, Ning-Wei Li, Esther Lee, Punam Thakkar, Robert S. Siegel, Christopher Badger, Jennifer Schottler, Joseph F. Goodman |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Swallowing Robotic Surgical Procedures Interquartile range Transoral robotic surgery Medicine Humans Stage (cooking) MD Anderson Dysphagia Inventory Aged Retrospective Studies business.industry Papillomavirus Infections Neck dissection Neoadjuvant Therapy Surgery Deglutition Oropharyngeal Neoplasms Cross-Sectional Studies Otorhinolaryngology Oropharyngeal Carcinoma Cohort Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 167(2) |
| ISSN: | 1097-6817 |
| Popis: | OBJECTIVE To evaluate 2-year follow-up swallowing function in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) who completed neoadjuvant chemotherapy and transoral robotic surgery (NAC+S). STUDY DESIGN Retrospective analysis of patients with OPSCC treated with NAC+S between 2010 and 2021. SETTING A single academic institution. METHODS This is a cross-sectional study of patient-reported swallowing function, assessed with the MD Anderson Dysphagia Inventory (MDADI) at least 2 years after completion of treatment. The inclusion criteria are patients with HPV+ OPSCC who underwent NAC+S at least 2 years ago. Those requiring adjuvant radiation or chemoradiation or experiencing relapse were excluded from the study. RESULTS Completed MDADIs were received from 37 patients at a median 3.8 years posttreatment (interquartile range, 2.0-8.6 years). Of those, 94.6% (n = 35) were male and 81.1% (n = 30) were White. The median age at OPSCC diagnosis was 59.0 years (interquartile range, 41-80 years). The most frequent primary subsite of OPSCC was the base of the tongue (n = 20, 54.1%), followed by the tonsils (n = 16, 43.2%). In addition, 75.7% (n = 28) had stage IVa disease (TNM seventh edition), and 29 (78.4%) had scores ≥80, classified as optimal function. When compared with patients who received bilateral neck dissection, patients who received unilateral neck dissection were associated with an age |
| Databáze: | OpenAIRE |
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