Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury
| Autor: | Shyam Gajavelli, Angelica Clavijo, Nissrine Ballout, Noël Ghanem, Zhen Hu, Naify Ramadan, Nabil Karnib, Daniela Caliz, Stefania Mondello, Ali I. Nabbouh, Kazem Zibara, Firas Kobeissy, Saad Omais |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Traumatic
0301 basic medicine Traumatic brain injury medicine.medical_treatment Neural degeneration Stem cells Neuroprotection Cell therapy 03 medical and health sciences Cellular and Molecular Neuroscience Clinical trials 0302 clinical medicine Drug-based therapy Brain Injuries Traumatic medicine Animals Humans Pharmacology Rehabilitation business.industry medicine.disease Combined Modality Therapy Neural stem cell Transplantation Neuroprotective Agents 030104 developmental biology Brain Injuries Stem cell Neurotrauma Stem Cell Transplantation business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuropharmacology. 145:177-198 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2018.09.032 |
| Popis: | Traumatic brain injury (TBI) has been recognized as one of the major public health issues that leads to devastating neurological disability. As a consequence of primary and secondary injury phases, neuronal loss following brain trauma leads to pathophysiological alterations on the molecular and cellular levels that severely impact the neuropsycho-behavioral and motor outcomes. Thus, to mitigate the neuropathological sequelae post-TBI such as cerebral edema, inflammation and neural degeneration, several neurotherapeutic options have been investigated including drug intervention, stem cell use and combinational therapies. These treatments aim to ameliorate cellular degeneration, motor decline, cognitive and behavioral deficits. Recently, the use of neural stem cells (NSCs) coupled with selective drug therapy has emerged as an alternative treatment option for neural regeneration and behavioral rehabilitation post-neural injury. Given their neuroprotective abilities, NSC-based neurotherapy has been widely investigated and well-reported in numerous disease models, notably in trauma studies. In this review, we will elaborate on current updates in cell replacement therapy in the area of neurotrauma. In addition, we will discuss novel combination drug therapy treatments that have been investigated in conjunction with stem cells to overcome the limitations associated with stem cell transplantation. Understanding the regenerative capacities of stem cell and drug combination therapy will help improve functional recovery and brain repair post-TBI. This article is part of the Special Issue entitled "Novel Treatments for Traumatic Brain Injury". |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect